Alzheimer's Disease-Related Lesions

被引:4
作者
Alafuzoff, Irina [1 ,2 ,3 ]
机构
[1] Uppsala Univ, Dept Immunol Genet & Pathol, S-75185 Uppsala, Sweden
[2] Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland
[3] Univ Uppsala Hosp, Dept Clin Pathol & Cytol, Uppsala, Sweden
关键词
Aging; Alzheimer's disease-related pathology; amyloid-beta; co-morbidity; hyperphosphorylated tau; immunohistochemistry; neuropathology; alpha-synuclein; BRAINNET EUROPE CONSORTIUM; LEWY BODIES; NEUROFIBRILLARY PATHOLOGY; NEUROPATHOLOGIC ASSESSMENT; PARKINSONS-DISEASE; APOLIPOPROTEIN-E; ALPHA-SYNUCLEIN; DIAGNOSIS; DEMENTIA; PLAQUES;
D O I
10.3233/JAD-2012-129024
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The invitation to contribute to "Alzheimer's Disease: Advances for a New Century" gave me an opportunity to briefly summarize my personal opinions about how the field of neuropathology has evolved. The goal is to briefly exemplify the changes that have influenced the way we conduct our diagnostic work as well as the way we interpret our results. From an era of histological stains, we have moved to visualization of altered proteins in predicted brain regions; we have also realized that in many aged subjects, not one but a plethora of co-pathologies are seen, and finally, we have become aware that the degenerative process is initiated much earlier than we ever suspected.
引用
收藏
页码:S173 / S179
页数:7
相关论文
共 48 条
[1]   Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjects [J].
Aho, Leena ;
Parkkinen, Laura ;
Pirttilae, Tuula ;
Alafuzoff, Irina .
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2008, 25 (05) :423-432
[2]   HISTOPATHOLOGICAL CRITERIA FOR PROGRESSIVE DEMENTIA DISORDERS - CLINICAL-PATHOLOGICAL CORRELATION AND CLASSIFICATION BY MULTIVARIATE DATA-ANALYSIS [J].
ALAFUZOFF, I ;
IQBAL, K ;
FRIDEN, H ;
ADOLFSSON, R ;
WINBLAD, B .
ACTA NEUROPATHOLOGICA, 1987, 74 (03) :209-225
[3]  
Alafuzoff I, 1999, ALZHEIMERS REP, V2, P283
[4]  
Alafuzoff I, 2000, J ALZHEIMERS DIS, V2, P1
[5]   Staging of neurofibrillary pathology in Alzheimer's disease:: A study of the BrainNet Europe consortium [J].
Alafuzoff, Irina ;
Arzberger, Thomas ;
Al-Sarraj, Safa ;
Bodi, Istvan ;
Bogdanovic, Nenad ;
Braak, Heiko ;
Bugiani, Orso ;
Del-Tredici, Kelly ;
Ferrer, Isidro ;
Gelpi, Ellen ;
Giaccone, Giorgio ;
Graeber, Manuel B. ;
Ince, Paul ;
Kamphorst, Wouter ;
King, Andrew ;
Korkolopoulou, Penelope ;
Kovacs, Gabor G. ;
Larionov, Sergey ;
Meyronet, David ;
Monoranu, Camelia ;
Parchi, Piero ;
Patsouris, Efstratios ;
Roggendorf, Wolfgang ;
Seilhean, Danielle ;
Tagliavini, Fabrizio ;
Stadelmann, Christine ;
Streichenberger, Nathalie ;
Thal, Dietmar R. ;
Wharton, Stephen B. ;
Kretzschmar, Hans .
BRAIN PATHOLOGY, 2008, 18 (04) :484-496
[6]   Inter-laboratory comparison of neuropathological assessments of β-amyloid protein:: a study of the BrainNet Europe consortium [J].
Alafuzoff, Irina ;
Pikkarainen, Maria ;
Arzberger, Thomas ;
Thal, Dietmar R. ;
Al-Sarraj, Safa ;
Bell, Jeanne ;
Bodi, Istvan ;
Budka, Herbert ;
Capetillo-Zarate, Estibaliz ;
Ferrer, Isidro ;
Gelpi, Ellen ;
Gentleman, Stephen ;
Giaccone, Giorgio ;
Kavantzas, Nikolaos ;
King, Andrew ;
Korkolopoulou, Penelope ;
Kovacs, Gabor G. ;
Meyronet, David ;
Monoranu, Camelia ;
Parchi, Piero ;
Patsouris, Efstratios ;
Roggendorf, Wolfgang ;
Stadelmann, Christine ;
Streichenberger, Nathalie ;
Tagliavini, Fabricio ;
Kretzschmar, Hans .
ACTA NEUROPATHOLOGICA, 2008, 115 (05) :533-546
[7]   Interlaboratory comparison of assessments of Alzheimer disease-related lesions:: a study of the BrainNet Europe consortium [J].
Alafuzoff, Irina ;
Pikkarainen, Maria ;
Al-Sarraj, Safa ;
Arzberger, Thomas ;
Bell, Jeanne ;
Bodi, Istvan ;
Bogdanovic, Nenad ;
Budka, Herbert ;
Bugiani, Orso ;
Ferrer, Isidro ;
Gelpi, Ellen ;
Giaccone, Giorgio ;
Graeber, Manuel B. ;
Hauw, Jean-Jacques ;
Kamphorst, Wouter ;
King, Andrew ;
Kopp, Nicolas ;
Korkolopoulou, Penelope ;
Kovacs, Gdbor G. ;
Meyronet, David ;
Parchi, Piero ;
Patsouris, Efstratios ;
Preusser, Matthias ;
Ravid, Rivka ;
Roggendorf, Wolfgang ;
Seilhean, Danielle ;
Streichenberger, Nathalie ;
Thal, Dietmar R. ;
Kretzschmar, Hans .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2006, 65 (08) :740-757
[8]   Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium [J].
Alafuzoff, Irina ;
Ince, Paul G. ;
Arzberger, Thomas ;
Al-Sarraj, Safa ;
Bell, Jeanne ;
Bodi, Istvan ;
Bogdanovic, Nenad ;
Bugiani, Orso ;
Ferrer, Isidro ;
Gelpi, Ellen ;
Gentleman, Stephen ;
Giaccone, Giorgio ;
Ironside, James W. ;
Kavantzas, Nikolaos ;
King, Andrew ;
Korkolopoulou, Penelope ;
Kovacs, Gabor G. ;
Meyronet, David ;
Monoranu, Camelia ;
Parchi, Piero ;
Parkkinen, Laura ;
Patsouris, Efstratios ;
Roggendorf, Wolfgang ;
Rozemuller, Annemieke ;
Stadelmann-Nessler, Christine ;
Streichenberger, Nathalie ;
Thal, Dietmar R. ;
Kretzschmar, Hans .
ACTA NEUROPATHOLOGICA, 2009, 117 (06) :635-652
[9]  
[Anonymous], 1997, Neurobiol Aging, V18, pS1
[10]   Staging of brain pathology related to sporadic Parkinson's disease [J].
Braak, H ;
Del Tredici, K ;
Rüb, U ;
de Vos, RAI ;
Steur, ENHJ ;
Braak, E .
NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211