Alzheimer's Disease-Related Lesions

被引：4

作者：

Alafuzoff, Irina ^{[1
,2
,3
]}

机构：

[1] Uppsala Univ, Dept Immunol Genet & Pathol, S-75185 Uppsala, Sweden

[2] Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland

[3] Univ Uppsala Hosp, Dept Clin Pathol & Cytol, Uppsala, Sweden

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 33卷

关键词：

Aging; Alzheimer's disease-related pathology; amyloid-beta; co-morbidity; hyperphosphorylated tau; immunohistochemistry; neuropathology; alpha-synuclein; BRAINNET EUROPE CONSORTIUM; LEWY BODIES; NEUROFIBRILLARY PATHOLOGY; NEUROPATHOLOGIC ASSESSMENT; PARKINSONS-DISEASE; APOLIPOPROTEIN-E; ALPHA-SYNUCLEIN; DIAGNOSIS; DEMENTIA; PLAQUES;

D O I：

10.3233/JAD-2012-129024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The invitation to contribute to "Alzheimer's Disease: Advances for a New Century" gave me an opportunity to briefly summarize my personal opinions about how the field of neuropathology has evolved. The goal is to briefly exemplify the changes that have influenced the way we conduct our diagnostic work as well as the way we interpret our results. From an era of histological stains, we have moved to visualization of altered proteins in predicted brain regions; we have also realized that in many aged subjects, not one but a plethora of co-pathologies are seen, and finally, we have become aware that the degenerative process is initiated much earlier than we ever suspected.

引用

页码：S173 / S179

页数：7

共 48 条

[41] The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae [J].

Petersen, Camilla A. Hansson ;

Alikhani, Nyosha ;

Behbahani, Homira ;

Wiehager, Birgitta ;

Pavlov, Pavel F. ;

Alafuzoff, Irina ;

Leinonen, Ville ;

Ito, Akira ;

Winblad, Bengt ;

Glaser, Elzbieta ;

Ankarcrona, Maria .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (35) :13145-13150

[42] The Effect of Prolonged Fixation Time on Immunohistochemical Staining of Common Neurodegenerative Disease Markers [J].

Pikkarainen, Maria ;

Martikainen, Paula ;

Alafuzoff, Irina .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2010, 69 (01) :40-52

[43] TAR-DNA binding protein-43 and alterations in the hippocampus [J].

Rauramaa, Tuomas ;

Pikkarainen, Maria ;

Englund, Elisabet ;

Ince, Paul G. ;

Jellinger, Kurt ;

Paetau, Anders ;

Alafuzoff, Irina .

JOURNAL OF NEURAL TRANSMISSION, 2011, 118 (05) :683-689

[44]

REBECK GW, 1993, NEURON, V11, P575

[45] Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease [J].

Salminen, Antero ;

Kaarniranta, Kai ;

Haapasalo, Annakaisa ;

Hiltunen, Mikko ;

Soininen, Hilkka ;

Alafuzoff, Irina .

PROGRESS IN NEUROBIOLOGY, 2012, 96 (01) :87-95

[46] INCREASED AMYLOID BETA-PEPTIDE DEPOSITION IN CEREBRAL-CORTEX AS A CONSEQUENCE OF APOLIPOPROTEIN-E GENOTYPE IN LATE-ONSET ALZHEIMER-DISEASE [J].

SCHMECHEL, DE ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

CRAIN, BJ ;

HULETTE, CM ;

JOO, SH ;

PERICAKVANCE, MA ;

GOLDGABER, D ;

ROSES, AD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) :9649-9653

[47] Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain [J].

Tapiola, Tero ;

Alafuzoff, Irina ;

Herukka, Sanna-Kaisa ;

Parkkinen, Laura ;

Hartikainen, Paivi ;

Soininen, Hilkka ;

Pirttila, Tuula .

ARCHIVES OF NEUROLOGY, 2009, 66 (03) :382-389

[48] COMPARISON OF 3 SILVER STAINS FOR DEMONSTRATING NEUROFIBRILLARY TANGLES AND NEURITIC PLAQUES IN BRAIN-TISSUE STORED FOR LONG PERIODS [J].

WILCOCK, GK ;

MATTHEWS, SM ;

MOSS, T .

ACTA NEUROPATHOLOGICA, 1990, 79 (05) :566-568

← 1 2 3 4 5 →