MAPKAP kinases - MKs - two's company, three's a crowd

被引：318

作者：

Gaestel, M ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Biochem, D-30625 Hannover, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 02期

关键词：

D O I：

10.1038/nrm1834

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs)-MK2, MK3 and MK5-signal to diverse cellular targets. Although there is no known common function for all three MKs, these kinases are involved in important processes: MKs regulate gene expression at the transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle progression, and are implicated in inflammation and cancer.

引用

页码：120 / 130

页数：11

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