Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes

被引：113

作者：

Blaschke, F

Takata, Y

Caglayan, E

Law, RE

Hsueh, WA

机构：

[1] Univ Calif Los Angeles, Div Endocrinol Diabet & Hypertens, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] German Heart Inst, Dept Med Cardiol, Berlin, Germany

[3] Takeda Pharmaceut N Amer Inc, Lincolnshire, IL USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2006年 / 26卷 / 01期

关键词：

PPARs; atherosclerosis; obesity; diabetes;

D O I：

10.1161/01.ATV.0000191663.12164.77

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. The 3 PPAR isotypes, PPAR-alpha, PPAR-gamma, and PPAR-delta, play a key role in the regulation of lipid and glucose metabolism. Obesity and the interrelated disorders of the metabolic syndrome have become a major worldwide health problem. In this review, we summarize the critical role of PPARs in regulating inflammation, lipoprotein metabolism, and glucose homeostasis and their potential implications for the treatment of obesity, diabetes, and atherosclerosis.

引用

收藏

页码：28 / 40

页数：13

相关论文

共 213 条

[1] Pathophysiological role of leptin in obesity-related hypertension [J].

Aizawa-Abe, M ;

Ogawa, Y ;

Masuzaki, H ;

Ebihara, K ;

Satoh, N ;

Iwai, H ;

Matsuoka, N ;

Hayashi, T ;

Hosoda, K ;

Inoue, G ;

Yoshimasa, Y ;

Nakao, K .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (09) :1243-1252

[2]

*AM HEART ASS, 2002, HEART STROK FACTS 20

[3] Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα) [J].

Aoyama, T ;

Peters, JM ;

Iritani, N ;

Nakajima, T ;

Furihata, K ;

Hashimoto, T ;

Gonzalez, FJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) :5678-5684

[4] MECHANISTICALLY-BASED HUMAN HAZARD ASSESSMENT OF PEROXISOME PROLIFERATOR-INDUCED HEPATOCARCINOGENESIS [J].

ASHBY, J ;

BRADY, A ;

ELCOMBE, CR ;

ELLIOTT, BM ;

ISHMAEL, J ;

ODUM, J ;

TUGWOOD, JD ;

KETTLE, S ;

PURCHASE, IFH .

HUMAN & EXPERIMENTAL TOXICOLOGY, 1994, 13 :S1-S117

[5] Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer [J].

Barak, Y ;

Liao, D ;

He, WM ;

Ong, ES ;

Nelson, MC ;

Olefsky, JM ;

Boland, R ;

Evans, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) :303-308

[6] Fatty acids and insulin resistance [J].

Boden, G .

DIABETES CARE, 1996, 19 (04) :394-395

[7] Free fatty acids in obesity and type 2 diabetes:: defining their role in the development of insulin resistance and β-cell dysfunction [J].

Boden, G ;

Shulman, GI .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 :14-23

[8] Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat [J].

Braissant, O ;

Foufelle, F ;

Scotto, C ;

Dauca, M ;

Wahli, W .

ENDOCRINOLOGY, 1996, 137 (01) :354-366

[9] Troglitazone action is independent of adipose tissue [J].

Burant, CF ;

Sreenan, S ;

Hirano, KI ;

Tai, TAC ;

Lohmiller, J ;

Lukens, J ;

Davidson, NO ;

Ross, S ;

Graves, RA .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (11) :2900-2908

[10] LOCATION AND REGULATION OF RAT ANGIOTENSINOGEN MESSENGER-RNA [J].

CASSIS, LA ;

SAYE, J ;

PEACH, MJ .

HYPERTENSION, 1988, 11 (06) :591-596

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