Polyhydroxylated pyrrolizidines. Part 1: Short and highly stereocontrolled syntheses of hyacinthacines

被引：42

作者：

Izquierdo, I ^{[1
]}

Plaza, MT ^{[1
]}

Robles, R ^{[1
]}

Franco, F ^{[1
]}

机构：

[1] Univ Granada, Dept Organ Chem, Fac Pharm, E-18071 Granada, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 17期

关键词：

D O I：

10.1016/S0957-4166(01)00440-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two short and highly stereocontrolled syntheses for 7a-epi-hyacinthacine A(2) (7-deoxyalexine) 3 and 5,7a-diepihyacinthacine A(3) 4 are, respectively, reported herein. An appropriately protected polyhydroxypyrrolidine. (2R,3R,4R,5S)-3,4-dibenzyloxy-N-benzyloxycarbonyl-2'-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine 5, readily available from D-fructose, was chosen as the chiral starting material. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2481 / 2487

页数：7

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