Poly(ADP-ribose) polymerase activity in different pathologies - The link to inflammation and infarction

被引：37

作者：

Beneke, Sascha ^{[1
]}

机构：

[1] Univ Konstanz, Mol Toxicol Grp, D-78457 Constance, Germany

来源：

EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 07期

关键词：

poly(ADP-ribose) polymerase; inflammation; NF kappa B; ischemia-reperfusion injury; cell death; reactive oxygen species;

D O I：

10.1016/j.exger.2008.04.008

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

DNA repair and aging are two phenomena closely connected to each other. The poly(ADP-ribosyl)ation reaction has been implicated in both of them. Poly(ADP-ribose) was originally discovered as an enzymatic reaction product after DNA damage. Soon it became evident that it is necessary for regulation of different repair pathways. Also, evidence accumulated that poly(ADP-ribose) formation capacity is at least correlated with the life span of mammalian species. As a NAD(+)-consuming process, poly(ADP-ribosyl)ation can lead to cell death by energy depletion. This finding opened the area for investigation of poly(ADP-ribose) polymerase activity and polymer formation in pathologies. This review provides an introduction into the wide and complex field of poly(ADP-ribosyl)ation in different pathologies with regards of cell death regulation, inflammation and resulting tissue damage. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：605 / 614

页数：10

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