High speed spectral domain polarization sensitive optical coherence tomography of the human retina

被引:194
作者
Götzinger, E [1 ]
Pircher, M [1 ]
Hitzenberger, CK [1 ]
机构
[1] Univ Vienna, Ctr Biomed Eng & Phys, A-1090 Vienna, Austria
来源
OPTICS EXPRESS | 2005年 / 13卷 / 25期
基金
奥地利科学基金会;
关键词
D O I
10.1364/OPEX.13.010217
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We developed a high-speed polarization sensitive optical coherence tomography (PS-OCT) system for retinal imaging based on spectral domain OCT. The system uses two spectrometers, one for each polarization channel, that operate in parallel at 20000 A-lines/s each. It provides reflectivity, retardation, and cumulative optic axis orientation simultaneously. We present our instrument and discuss the requirements for the alignment of the two spectrometers specific for our setup. We show 2D spectral domain PS-OCT images and - to the best of our knowledge - the first 3D spectral domain PS-OCT data sets in form of fly-through movies and volume rendered data sets recorded in human retina in vivo. (c) 2005 Optical Society of America.
引用
收藏
页码:10217 / 10229
页数:13
相关论文
共 39 条
[1]   Polarization-sensitive optical coherence tomography of dental structures [J].
Baumgartner, A ;
Dichtl, S ;
Hitzenberger, CK ;
Sattmann, H ;
Robl, B ;
Moritz, A ;
Fercher, ZF ;
Sperr, W .
CARIES RESEARCH, 2000, 34 (01) :59-69
[2]  
Bouma B.E., 2002, Handbook of Optical Coherence Tomography
[3]  
Bracewell R., 2000, FOURIER TRANSFORM IT
[4]   BIREFRINGENCE OF THE HUMAN FOVEAL AREA ASSESSED INVIVO WITH MUELLER-MATRIX ELLIPSOMETRY [J].
BRINK, HBK ;
VANBLOKLAND, GJ .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1988, 5 (01) :49-57
[5]   Spectral-domain polarization-sensitive optical coherence tomography at 850 nm [J].
Cense, B ;
Chen, TC ;
Mujat, M ;
Joo, C ;
Akkin, T ;
Park, BH ;
Pierce, MC ;
Yun, A ;
Bouma, BE ;
Teamey, GJ ;
de Boer, JF .
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, 2005, 5690 :159-162
[6]   In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography [J].
Cense, B ;
Chen, TC ;
Park, BH ;
Pierce, MC ;
de Boer, JF .
OPTICS LETTERS, 2002, 27 (18) :1610-1612
[7]  
CENSE B, 2005, THESIS TWENTE U
[8]   TEST-RETEST VARIABILITY OF TOPOGRAPHIC MEASUREMENTS WITH CONFOCAL SCANNING LASER TOMOGRAPHY IN PATIENTS WITH GLAUCOMA AND CONTROL SUBJECTS [J].
CHAUHAN, BC ;
LEBLANC, RP ;
MCCORMICK, TA ;
ROGERS, JB .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1994, 118 (01) :9-15
[9]   Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].
Choma, MA ;
Sarunic, MV ;
Yang, CH ;
Izatt, JA .
OPTICS EXPRESS, 2003, 11 (18) :2183-2189
[10]   Effect of individualized compensation for anterior segment birefringence on retinal nerve fiber layer assessments as determined by scanning laser polarimetry [J].
Choplin, NT ;
Zhou, QY ;
Knighton, RW .
OPHTHALMOLOGY, 2003, 110 (04) :719-725