An efficient synthesis of N-alpha-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine

被引：77

作者：

Solas, D

Hale, RL

Patel, DV

机构：

[1] Affymax Research Institute, Santa Clara, CA 95051

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 04期

关键词：

D O I：

10.1021/jo9517508

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[No abstract available]

引用

页码：1537 / 1539

页数：3

共 13 条

[1] NEW INTRACELLULAR TARGETS FOR THERAPEUTIC DRUG DESIGN [J].

BRUGGE, JS .

SCIENCE, 1993, 260 (5110) :918-919

[2] SYNTHESIS OF 4-PHOSPHONO(DIFLUOROMETHYL)-D, L-PHENYLALANINE AND N-BOC AND N-FMOC DERIVATIVES SUITABLY PROTECTED FOR SOLID-PHASE SYNTHESIS OF NONHYDROLYZABLE PHOSPHOTYROSYL PEPTIDE ANALOGS [J].

BURKE, TR ;

SMYTH, MS ;

OTAKA, A ;

ROLLER, PP .

TETRAHEDRON LETTERS, 1993, 34 (26) :4125-4128

[3] PREPARATION OF FLUORO-4-(PHOSPHONOMETHYL)-D,L-PHENYLALANINE AND HYDROXY-4-(PHOSPHONOMETHYL)-D,L-PHENYLALANINE SUITABLY PROTECTED FOR SOLID-PHASE SYNTHESIS OF PEPTIDES CONTAINING HYDROLYTICALLY STABLE ANALOGS OF O-PHOSPHOTYROSINE [J].

BURKE, TR ;

SMYTH, MS ;

NOMIZU, M ;

OTAKA, A ;

ROLLER, PP .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (06) :1336-1340

[4]

Castro B., 1975, Tetrahedron Lett, V16, P1219, DOI [10.1016/S0040-4039(00)72100-9, DOI 10.1016/S0040-4039(00)72100-9]

[5] THE WHEN AND HOW OF SRC REGULATION [J].

COOPER, JA ;

HOWELL, B .

CELL, 1993, 73 (06) :1051-1054

[6] PREPARATION OF AN ANGIOTENSIN-I ANALOG CONTAINING A PARA-PHOSPHONOMETHYL-L-PHENYLALANINE RESIDUE VIA ASYMMETRIC-SYNTHESIS OF TERT-BOC-PARA-DIMETHYLPHOSPHONOMETHYL-L-PHENYLALANINE [J].

CUSHMAN, M ;

LEE, ES .

TETRAHEDRON LETTERS, 1992, 33 (09) :1193-1196

[7] INHIBITION OF SH2 DOMAIN PHOSPHOPROTEIN ASSOCIATION BY A NONHYDROLYZABLE PHOSPHONOPEPTIDE [J].

DOMCHEK, SM ;

AUGER, KR ;

CHATTERJEE, S ;

BURKE, TR ;

SHOELSON, SE .

BIOCHEMISTRY, 1992, 31 (41) :9865-9870

[8] A STEREOCONTROLLED TOTAL SYNTHESIS OF OPTICALLY-ACTIVE (R,R)-PHYTOL [J].

FUJISAWA, T ;

SATO, T ;

KAWARA, T ;

OHASHI, K .

TETRAHEDRON LETTERS, 1981, 22 (48) :4823-4826

[9] N-ALPHA-FMOC-4-PHOSPHONO(DIFLUOROMETHYL)-L-PHENYLALANINE - A NEW O-PHOSPHOTYROSINE ISOSTERIC BUILDING-BLOCK SUITABLE FOR DIRECT INCORPORATION INTO PEPTIDES [J].

GORDEEV, MF ;

PATEL, DV ;

BARKER, PL ;

GORDON, EM .

TETRAHEDRON LETTERS, 1994, 35 (41) :7585-7588

[10] DEPROTECTION AND CLEAVAGE METHODS FOR PROTECTED PEPTIDE RESINS CONTAINING 4-[(DIETHYLPHOSPHONO)DIFLUOROMETHYL]-D,L-PHENYLALANINE RESIDUES [J].

OTAKA, A ;

BURKE, TR ;

SMYTH, MS ;

NOMIZU, M ;

ROLLER, PP .

TETRAHEDRON LETTERS, 1993, 34 (44) :7039-7042

← 1 2 →