The Origins and Drivers of Insulin Resistance

被引:553
作者
Johnson, Andrew M. F. [1 ]
Olefsky, Jerrold M. [1 ]
机构
[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
关键词
DIET-INDUCED OBESITY; HIGH-FAT DIET; NECROSIS-FACTOR-ALPHA; KILLER T-CELLS; ADIPOSE-TISSUE; GUT MICROBIOTA; METABOLIC-SYNDROME; PPAR-GAMMA; MOLECULAR-MECHANISMS; GLUCOSE-TOLERANCE;
D O I
10.1016/j.cell.2013.01.041
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which precedes the development of type 2 diabetes mellitus and is thus the driving force behind the emerging diabetes epidemic. The precise causes of insulin resistance are varied, and the relative importance of each is a matter of ongoing research. Here, we offer a Perspective on the heterogeneous etiology of insulin resistance, focusing in particular on the role of inflammation, lipid metabolism, and the gastrointestinal microbiota.
引用
收藏
页码:673 / 684
页数:12
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