NETosis: how vital is it?

被引：782

作者：

Yipp, Bryan G. ^{[1
,2
,3
]}

Kubes, Paul ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calgary, Snyder Inst Chron Dis, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Fac Med, Dept Crit Care Med, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Immunol Res Grp, Calgary, AB T2N 4N1, Canada

[4] Univ Calgary, Fac Med, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada

来源：

BLOOD | 2013年 / 122卷 / 16期

关键词：

NEUTROPHIL EXTRACELLULAR TRAPS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; NUCLEAR-ENVELOPE BREAKDOWN; GROUP-A STREPTOCOCCUS; STAPHYLOCOCCUS-AUREUS; POLYMORPHONUCLEAR LEUKOCYTES; NETTING NEUTROPHILS; ENDOTHELIAL-CELLS; MITOCHONDRIAL-DNA; INNATE IMMUNITY;

D O I：

10.1182/blood-2013-04-457671

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this review, we examine the evidence that neutrophil extracellular traps (NETs) play a critical role in innate immunity. We summarize how NETs are formed in response to various stimuli and provide evidence that NETosis is not universally a cell death pathway. Here we describe at least 2 different mechanisms by which NETs are formed, including a suicide lytic NETosis and a live cell or vital NETosis. We also evaluate the evidence for NETs in catching and killing pathogens. Finally, we examine how infections are related to the development of autoimmune and vasculitic diseases through unintended but detrimental bystander damage resulting from NET release.

引用

页码：2784 / 2794

页数：11

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