Relationship between serum bilirubin and albuminuria in patients with type 2 diabetes

被引：104

作者：

Fukui, Michiaki ^{[1
]}

Tanaka, Muhei ^{[1
]}

Shiraishi, Emi ^{[1
]}

Harusato, Ichiko ^{[1
]}

Hosoda, Hiroko ^{[1
]}

Asano, Mai ^{[1
]}

Hasegawa, Goji ^{[1
]}

Nakamura, Naoto ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kamigyo Ku, Kyoto 6028566, Japan

来源：

KIDNEY INTERNATIONAL | 2008年 / 74卷 / 09期

关键词：

bilirubin; albuminuria; type; 2; diabetes; oxidative stress; atherosclerosis; cardiovascular disease;

D O I：

10.1038/ki.2008.398

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies showed that low serum bilirubin concentrations are associated with increased risk of cardiovascular disease. To explore this further, we evaluated the relationships between serum bilirubin concentrations and the degree of urinary albumin excretion and other markers of subclinical atherosclerosis in 633 consecutive patients with type 2 diabetes. Multiple regression analysis showed that the serum bilirubin concentration was an independent determinant of and had a significant inverse correlation to the log urinary albumin excretion. Serum bilirubin concentrations were significantly lower in patients with than in those without cardiovascular disease. A significant inverse correlation was found between the serum bilirubin concentration and pulse wave velocity, while a significant positive correlation was found to the ankle-brachial index in a subgroup of 386 patients. Our study shows that the serum bilirubin level is associated with microalbuminuria and subclinical atherosclerosis in patients with type 2 diabetes.

引用

页码：1197 / 1201

页数：5

共 27 条

[1] Balloon injury does not induce heme oxygenase-1 expression, but administration of hemin inhibits neointimal formation in balloon-injured rat carotid artery [J].