Simple and Direct sp3 C-H Bond Arylation of Tetrahydroisoquinolines and Isochromans via 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Oxidation under Mild Conditions

被引：96

作者：

Muramatsu, Wataru ^{[1
]}

Nakano, Kimihiro ^{[1
]}

Li, Chao-Jun ^{[2
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan

[2] McGill Univ, Dept Chem, Montreal, PQ H3A 0B8, Canada

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 14期

关键词：

SOLIFENACIN SUCCINATE; BENZYLIC ALCOHOLS; CITRININ DIMERS; FUNCTIONALIZATION; DERIVATIVES; EFFICIENT; FUNGUS; ACID;

D O I：

10.1021/ol401534g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated sp(3) C-H bond arylation of tetrahydroisoquinolines and isochromans is described. The corresponding products were facilely synthesized via a simple nucleophilic addition reaction between readily available aryl Grignard reagents and iminium (or oxonium) cations generated in situ by DDQ oxidation of tetrahydroisoquinolines (or isochromans) under mild conditions.

引用

页码：3650 / 3653

页数：4

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