Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins

被引：101

作者：

Wang, Guangshun ^{[1
]}

Watson, Karen M. ^{[2
]}

Buckheit, Robert W., Jr. ^{[2
]}

机构：

[1] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Struct Fun Lab, Omaha, NE 68198 USA

[2] ImQuest BioSci Inc, Frederick, MD 21704 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 09期

关键词：

D O I：

10.1128/AAC.00452-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

From among 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest peptide active against human immunodeficiency virus (HIV) and GI-20 had the highest therapeutic index, which was twice that of LL-37. BMAP-18, which is derived from bovine cathelicidin BMAP-27, possessed a therapeutic index similar to that of GI-20. Peptide sequence order, helical structures, and aromatic residues are important in HIV inhibition.

引用

页码：3438 / 3440

页数：3

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