Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins

被引：101

作者：

Wang, Guangshun ^{[1
]}

Watson, Karen M. ^{[2
]}

Buckheit, Robert W., Jr. ^{[2
]}

机构：

[1] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Struct Fun Lab, Omaha, NE 68198 USA

[2] ImQuest BioSci Inc, Frederick, MD 21704 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 09期

关键词：

D O I：

10.1128/AAC.00452-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

From among 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest peptide active against human immunodeficiency virus (HIV) and GI-20 had the highest therapeutic index, which was twice that of LL-37. BMAP-18, which is derived from bovine cathelicidin BMAP-27, possessed a therapeutic index similar to that of GI-20. Peptide sequence order, helical structures, and aromatic residues are important in HIV inhibition.

引用

页码：3438 / 3440

页数：3

共 37 条

[11] Human α- and β-defensins block multiple steps in herpes simplex virus infection [J].

Hazrati, Ehsan ;

Galen, Benjamin ;

Lu, Wuyuan ;

Wang, Wei ;

Yan Ouyang ;

Keller, Marla J. ;

Lehrer, Robert I. ;

Herold, Betsy C. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (12) :8658-8666

[12] Peptide antimicrobial agents [J].

Jenssen, Havard ;

Hamill, Pamela ;

Hancock, Robert E. W. .

CLINICAL MICROBIOLOGY REVIEWS, 2006, 19 (03) :491-+

[13] Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region [J].

Li, X ;

Li, YF ;

Han, HY ;

Miller, DW ;

Wang, GS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (17) :5776-5785

[14] NMR studies of aurein 1.2 analogs [J].

Li, Xia ;

Li, Yifeng ;

Peterkofsky, Alan ;

Wang, Guangshun .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2006, 1758 (09) :1203-1214

[15] The antimicrobial peptide Dermaseptin S4 inhibits HIV-1 infectivity in vitro [J].

Lorin, C ;

Saidi, H ;

Belaid, A ;

Zairi, A ;

Baleux, F ;

Hocini, H ;

Bélec, L ;

Hani, K ;

Tangy, F .

VIROLOGY, 2005, 334 (02) :264-275

[16] Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites [J].

Marchand, Christophe ;

Krajewski, Krzysztof ;

Lee, Hsiu-Fang ;

Antony, Smitha ;

Johnson, Allison A. ;

Amin, Ronak ;

Roller, Peter P. ;

Kvaratskhelia, Mamuka ;

Pommier, Yves .

NUCLEIC ACIDS RESEARCH, 2006, 34 (18) :5157-5165

[17] Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus [J].

Matanic, VCA ;

Castilla, V .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 23 (04) :382-389

[18] The θ-defensin, retrocyclin, inhibits HIV-1 entry [J].

Münk, C ;

Wei, G ;

Yang, OO ;

Waring, AJ ;

Wang, W ;

Hong, T ;

Lehrer, RI ;

Landau, NR ;

Cole, AM .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2003, 19 (10) :875-881

[19] Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense [J].

Murakami, M ;

Lopez-Garcia, B ;

Braff, M ;

Dorschner, RA ;

Gallo, RL .

JOURNAL OF IMMUNOLOGY, 2004, 172 (05) :3070-3077

[20] Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues [J].

Nagaoka, I ;

Hirota, S ;

Niyonsaba, F ;

Hirata, M ;

Adachi, Y ;

Tamura, H ;

Tanaka, S ;

Heumann, D .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2002, 9 (05) :972-982

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