Olfactory experience accelerates glomerular refinement in the mammalian olfactory bulb

被引：69

作者：

Kerr, MA ^{[1
]}

Belluscio, L ^{[1
]}

机构：

[1] NINDS, Dev Neural Plast Unit, NIH, Bethesda, MD 20892 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 04期

关键词：

D O I：

10.1038/nn1673

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Primary olfactory sensory neurons (OSNs) impart both molecular and functional organization to the olfactory bulb. Because OSNs can be selectively activated by odorants in vivo, we sought to determine whether odorant experience alters the cellular dynamics of specific OSNs or their axonal projections. Using mice, we found that odorant stimulation associated with behavioral conditioning influenced OSN wiring by accelerating glomerular refinement independent of OSN number; furthermore, this wiring was strongly associated with olfactory learning.

引用

页码：484 / 486

页数：3

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