MRI-controlled regional hyperthermia

被引:14
作者
Peller, M
Löffler, R
Baur, A
Turner, P
Abdel-Rahman, S
Futschik, G
Santl, M
Hiddemann, W
Reiser, M
Issels, R
机构
[1] Klinikum Ludwig Maximilians Univ, Inst Radiol Diagnost, D-81377 Munich, Germany
[2] Siemens Med Tech AG, Erlangen, Germany
[3] BSD Med Corp, Salt Lake City, UT USA
[4] GSF Forschungszentrum Umwelt & Gesundheit, Munich, Germany
[5] GSF Forschungszentrum Umwelt & Gesundheit, Neuherberg, Germany
[6] Klinikum Ludwig Maximilians Univ, Med Klin 3, D-81377 Munich, Germany
[7] Dr Sennewald Med Tech GMBH, Munich, Germany
来源
RADIOLOGE | 1999年 / 39卷 / 09期
关键词
MRI; regional hyperthermia; soft-tissue tumors; bone tumors;
D O I
10.1007/s001170050572
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: Regional hyperthermia in combination with chemotherapy or/and radiotherapy is a promising treatment concept for locally advanced, deep-seated tumors. The purpose of the project is the optimization of the therapy using non-invasive, three-dimensionaI imaging of tissue changes or of the temperature distribution during regional hyperthermia. Methods: MRI offers methods suitable in principle for tissue characterization and MR thermometry. A new MRI-hyperthermia hybrid system has been developed based on an innovative hyperthermia applicator and an open MRI system. Results: After successful testing of the new MRI-hyperthermia hybrid system simultaneous MRI and regional hyperthermia in patients could be accomplished for the first time. At present the T1 relaxation time seems to be a promising parameter for MR thermometry. Conclusion:The first clinical application of the MRI-hyperthermia hybrid system can be regarded as an important step towards the development of regional hyperthermia. This new hybrid system and the MR thermometry methods have to be investigated prospectively in clinical studies.
引用
收藏
页码:756 / 763
页数:8
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