Enzyme assisted synthesis of D-myo-inositol-1,2,6-trisphosphate

被引:10
作者
Andersch, P [1 ]
Schneider, MP [1 ]
机构
[1] BERG UNIV GESAMTHSCH WUPPERTAL, FB 9, D-42097 WUPPERTAL, GERMANY
关键词
D O I
10.1016/0957-4166(96)00003-1
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The title compound is prepared in enantiomerically pure form via a facile enzyme assisted route. Essential for the success of the described method were a) the highly enantioselective esterification of 4,6-O-dibenzoyl-myo-inositol 2, b) the selective acylation of the axial hydroxyl function in 3 and c) the selective, base catalysed methanolysis of one benzoate group in 5. The obtained, selectively protected 1,2,6-triol 6 was converted into the title compound 7 by phosphorylation using N,N-dimethyl dibenzyl phosphoamidite followed by deprotection.
引用
收藏
页码:349 / 352
页数:4
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