PREPARATIVE-SCALE CHEMOENZYMATIC SYNTHESIS OF OPTICALLY PURE D-MYO-INOSITOL-1-PHOSPHATE

被引：37

作者：

LAUMEN, K

GHISALBA, O

机构：

[1] Pharmaceuticals Division, Core Drug Discovery Technologies, Basel, Ciba-Geigy AG

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1994年 / 58卷 / 11期

关键词：

D O I：

10.1271/bbb.58.2046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

D-myo-Inositol-1-phosphate was synthesized by a short and facile route from optically pure 1D-1-acetoxy-4,6-di-0-benzyl-myo-inositol, which was easily obtained by a highly regio- and enantioselective enzyme-catalyzed acetylation of 4,6-di-0-benzyl-myo-inositol.

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页码：2046 / 2049

页数：4

相关论文

共 40 条

[1] THE REGIOSELECTIVE SYNTHESIS OF ENANTIOMERICALLY PURE MYOINOSITOL DERIVATIVES - EFFICIENT SYNTHESIS OF MYOINOSITOL 1,4,5-TRISPHOSPHATE [J].

AGUILO, A ;

MARTINLOMAS, M ;

PENADES, S .

TETRAHEDRON LETTERS, 1992, 33 (03) :401-404

[2] CHIRAL SYNTHESIS OF D-MYO-INOSITOL 1-PHOSPHATE STARTING FROM L-QUEBRACHITOL [J].

AKIYAMA, T ;

TAKECHI, N ;

OZAKI, S .

TETRAHEDRON LETTERS, 1990, 31 (10) :1433-1434

[3] ENZYME ASSISTED SYNTHESIS OF ENANTIOMERICALLY PURE MYOINOSITOL DERIVATIVES - CHIRAL BUILDING-BLOCKS FOR INOSITOL POLYPHOSPHATES [J].

ANDERSCH, P ;

SCHNEIDER, MP .

TETRAHEDRON-ASYMMETRY, 1993, 4 (10) :2135-2138

[4]

ARBUZOV BA, 1982, IAN SSSR KH, V3, P588

[5] A SYNTHESIS OF 1D-MYO-INSITOL AND 1L-MYO-INOSITOL 1,3,4,5-TETRAPHOSPHATE [J].

BAUDIN, G ;

GLANZER, BI ;

SWAMINATHAN, KS ;

VASELLA, A .

HELVETICA CHIMICA ACTA, 1988, 71 (05) :1367-1378

[6] INOSITOL PHOSPHATES AND CELL SIGNALING [J].

BERRIDGE, MJ ;

IRVINE, RF .

NATURE, 1989, 341 (6239) :197-205

[7] NEURAL AND DEVELOPMENTAL ACTIONS OF LITHIUM - A UNIFYING HYPOTHESIS [J].

BERRIDGE, MJ ;

DOWNES, CP ;

HANLEY, MR .

CELL, 1989, 59 (03) :411-419

[8] LITHIUM AMPLIFIES AGONIST-DEPENDENT PHOSPHATIDYLINOSITOL RESPONSES IN BRAIN AND SALIVARY-GLANDS [J].

BERRIDGE, MJ ;

DOWNES, CP ;

HANLEY, MR .

BIOCHEMICAL JOURNAL, 1982, 206 (03) :587-595

[9] SYNTHESIS OF MYOINOSITOL 1-PHOSPHATE AND 4-PHOSPHATE, AND OF THEIR INDIVIDUAL ENANTIOMERS [J].

BILLINGTON, DC ;

BAKER, R ;

KULAGOWSKI, JJ ;

MAWER, IM .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (04) :314-316

[10] PRACTICAL SYNTHESIS OF ENANTIOMERICALLY PURE MYOINOSITOL DERIVATIVES [J].

BRUZIK, KS ;

MYERS, J ;

TSAI, MD .

TETRAHEDRON LETTERS, 1992, 33 (08) :1009-1012

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