2,2-Dicyanovinyl as a nonaromatic aryl bioisostere:: Synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands

被引：32

作者：

Haubmann, C ^{[1
]}

Hübner, H ^{[1
]}

Gmeiner, P ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Pharm & Lebensmittelchem, D-91052 Erlangen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00302-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The phenylpiperazinylmethyl substituted pyrrolylmethylenemalononitriles of type 3 and 4 were synthesized and evaluated as strong and selective dopamine D4 receptor ligands. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1969 / 1972

页数：4

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