BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia

被引：87

作者：

Rybakowski, Janusz K. ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Dept Adult Psychiat, PL-60572 Poznan, Poland

来源：

PHARMACOGENOMICS | 2008年 / 9卷 / 11期

关键词：

brain-derived neurotrophic factor; mood disorders; schizophrenia; Val66Met polymorphism;

D O I：

10.2217/14622416.9.11.1589

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The brain-derived neurotrophic factor (BDNF) gene has become a candidate gene for molecular-genetic studies of mood disorders and schizophrenia, and also for pharmacogenomics of drugs used in the treatment of these conditions, such as mood-stabilizers in bipolar mood disorder, antidepressants in depression, and antipsychotics in schizophrenia. it has been demonstrated that the functional Val66Met polymorphism of the gene can be associated with a number of clinical and pharmacological phenomena in these illnesses.

引用

页码：1589 / 1593

页数：5

共 50 条

[1] BDNF in schizophrenia, depression and corresponding animal models [J].

Angelucci, F ;

Brenè, S ;

Mathé, AA .

MOLECULAR PSYCHIATRY, 2005, 10 (04) :345-352

[2] Lack of association between two polymorphisms of brain-derived neurotrophic factor and response to typical neuroleptics [J].

Anttila, S ;

Illi, A ;

Kampman, O ;

Mattila, KM ;

Lehtimäki, T ;

Leinonen, E .

JOURNAL OF NEURAL TRANSMISSION, 2005, 112 (07) :885-890

[3] Schizophrenia, a neurodegenerative disorder with neurodevelopmental antecedents [J].

Ashe, PC ;

Berry, MD ;

Boulton, AA .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2001, 25 (04) :691-707

[4] Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs [J].

Bai, O ;

Chlan-Fourney, J ;

Bowen, R ;

Keegan, D ;

Li, XM .

JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 71 (01) :127-131

[5] Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication [J].

Chen, B ;

Dowlatshahi, D ;

MacQueen, GM ;

Wang, JF ;

Young, LT .

BIOLOGICAL PSYCHIATRY, 2001, 50 (04) :260-265

[6] Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder [J].

Choi, Myoung-Jin ;

Kang, Rhee-Hun ;

Lim, Se-Won ;

Oh, Kang-Seob ;

Lee, Min-Soo .

BRAIN RESEARCH, 2006, 1118 :176-182

[7] Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses [J].

Durany, N ;

Michel, T ;

Zöchling, R ;

Boissl, KW ;

Cruz-Sánchez, FF ;

Riederer, P ;

Thome, J .

SCHIZOPHRENIA RESEARCH, 2001, 52 (1-2) :79-86

[8] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function [J].

Egan, MF ;

Kojima, M ;

Callicott, JH ;

Goldberg, TE ;

Kolachana, BS ;

Bertolino, A ;

Zaitsev, E ;

Gold, B ;

Goldman, D ;

Dean, M ;

Lu, B ;

Weinberger, DR .

CELL, 2003, 112 (02) :257-269

[9] Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder [J].

Frey, Benicio N. ;

Walss-Bass, Consuelo ;

Stanley, Jeffrey A. ;

Nery, Fabiano G. ;

Matsuo, Koji ;

Nicoletti, Mark A. ;

Hatch, John P. ;

Bowden, Charles L. ;

Escamilla, Michael A. ;

Soares, Jair C. .

NEUROREPORT, 2007, 18 (15) :1567-1570

[10] Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain [J].

Fukumoto, T ;

Morinobu, S ;

Okamoto, Y ;

Kagaya, A ;

Yamawaki, S .

PSYCHOPHARMACOLOGY, 2001, 158 (01) :100-106

← 1 2 3 4 5 →