Application of oxathiazolidine-S-oxide chemistry to the large-scale single-step synthesis of an O-arylethanolamine

被引：2

作者：

Barker, AC

Boardman, KA

Broady, SD

Moss, WO

Patel, B

Senior, MW

Warren, KEH

机构：

[1] Zeneca Pharmaceut, Proc Dev Dept, Macclesfield SK10 2NA, Cheshire, England

[2] Avlon Works, Proc Dev Dept, Bristol BS10 7ZE, Avon, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 1999年 / 3卷 / 04期

关键词：

D O I：

10.1021/op9800865

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Alternative routes to the arylethanolamine subunit of a development drug have been investigated. The selected route, involving O-alkylation of a phenol using N-benzyloxathiazolidine-S-oxide, was developed to give a process used successfully for pilot plant manufacture.

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收藏

页码：253 / 255

页数：3

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