A practical synthesis of L-ribose

被引：29

作者：

Akagi, M ^{[1
]}

Omae, D ^{[1
]}

Tamura, Y ^{[1
]}

Ueda, T ^{[1
]}

Kumashiro, T ^{[1
]}

Urata, H ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Osaka 5691094, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 06期

关键词：

mirror image; L-ribose; L-RNA; L-nucleoside;

D O I：

10.1248/cpb.50.866

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

L-Ribose was synthesized by a simple four-step method with overall yield of 76.3% from a protected L-arabinose derivative, which is a compatible intermediate for the synthesis of l: deoxyribose. The key step of this strategy is the Swern oxidation and subsequent stereo selective reduction accompanied by inversion of the 2-hydroxy group of protected L-arabinose.

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收藏

页码：866 / 868

页数：3

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