General and specific immunosuppression caused by antiviral T-cell responses

被引:42
作者
Zinkernagel, RM [1 ]
Planz, O [1 ]
Ehl, S [1 ]
Battegay, M [1 ]
Odermatt, B [1 ]
Klenerman, P [1 ]
Hengartner, H [1 ]
机构
[1] Univ Zurich, Inst Expt Immunol, Dept Pathol, CH-8091 Zurich, Switzerland
关键词
D O I
10.1111/j.1600-065X.1999.tb01300.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunosuppression caused by the non-cytopathic lymphocytic choriomeningitis virus (LCMV) (an RNA virus) is mediated by antiviral cytotoxic T cells that destroy LCMV-infected cells, also of the immune system. While this immunopathological destruction of antigen-presenting cells, macrophages and follicular dendritic cells and of some CD4(+) T cells causes general immunosuppression and impairs immune response to third party antigens, it also enhances exhaustion/deletion of LCMV-specific CD8(+) T-cell responses. LCMV seems in addition to infect neutralizing antibody-producing B cells via the specific receptor; immunopathological LCMV-specific CD8(+) T-cell-mediated elimination of these infected B cells (but not of uninfected internal virus antigen-specific B cells) causes a highly specific immunosuppression that delays neutralizing antibody responses and thereby enhances virus persistence. Both generalized and specific immunosuppression by CD8(+) T-cell-mediated immunopathology may be involved in human infections with HIV, hepatitis B virus or hepatitis C virus.
引用
收藏
页码:305 / 315
页数:11
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