General and specific immunosuppression caused by antiviral T-cell responses

被引:42
作者
Zinkernagel, RM [1 ]
Planz, O [1 ]
Ehl, S [1 ]
Battegay, M [1 ]
Odermatt, B [1 ]
Klenerman, P [1 ]
Hengartner, H [1 ]
机构
[1] Univ Zurich, Inst Expt Immunol, Dept Pathol, CH-8091 Zurich, Switzerland
关键词
D O I
10.1111/j.1600-065X.1999.tb01300.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunosuppression caused by the non-cytopathic lymphocytic choriomeningitis virus (LCMV) (an RNA virus) is mediated by antiviral cytotoxic T cells that destroy LCMV-infected cells, also of the immune system. While this immunopathological destruction of antigen-presenting cells, macrophages and follicular dendritic cells and of some CD4(+) T cells causes general immunosuppression and impairs immune response to third party antigens, it also enhances exhaustion/deletion of LCMV-specific CD8(+) T-cell responses. LCMV seems in addition to infect neutralizing antibody-producing B cells via the specific receptor; immunopathological LCMV-specific CD8(+) T-cell-mediated elimination of these infected B cells (but not of uninfected internal virus antigen-specific B cells) causes a highly specific immunosuppression that delays neutralizing antibody responses and thereby enhances virus persistence. Both generalized and specific immunosuppression by CD8(+) T-cell-mediated immunopathology may be involved in human infections with HIV, hepatitis B virus or hepatitis C virus.
引用
收藏
页码:305 / 315
页数:11
相关论文
共 80 条
[11]   Induction of long-lived germinal centers associated with persisting antigen after viral infection [J].
Bachmann, MF ;
Odermatt, B ;
Hengartner, H ;
Zinkernagel, RM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (05) :2259-2269
[12]   Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without ''memory T cells''? [J].
Bachmann, MF ;
Kundig, TM ;
Hengartner, H ;
Zinkernagel, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (02) :640-645
[13]   The influence of virus structure on antibody responses and virus serotype formation [J].
Bachmann, MF ;
Zinkernagel, RM .
IMMUNOLOGY TODAY, 1996, 17 (12) :553-558
[14]   ENHANCED ESTABLISHMENT OF A VIRUS CARRIER STATE IN ADULT CD4+ T-CELL-DEFICIENT MICE [J].
BATTEGAY, M ;
MOSKOPHIDIS, D ;
RAHEMTULLA, A ;
HENGARTNER, H ;
MAK, TW ;
ZINKERNAGEL, RM .
JOURNAL OF VIROLOGY, 1994, 68 (07) :4700-4704
[15]  
BATTEGAY M, 1993, J IMMUNOL, V151, P5408
[16]  
BIBERFELD P, 1985, CANCER RES, V45, P4665
[17]   VIRUS-INDUCED IMMUNOSUPPRESSION - IMMUNE SYSTEM-MEDIATED DESTRUCTION OF VIRUS-INFECTED DENDRITIC CELLS RESULTS IN GENERALIZED IMMUNE SUPPRESSION [J].
BORROW, P ;
EVANS, CF ;
OLDSTONE, MBA .
JOURNAL OF VIROLOGY, 1995, 69 (02) :1059-1070
[18]  
BROJORGENSEN K, 1974, INFECT IMMUN, V9, P605
[19]   Neutralizing antibodies are positively associated with CD4+ T-cell counts and T-cell function in long-term AIDS-free infection [J].
Carotenuto, P ;
Looij, D ;
Keldermans, L ;
de Wolf, F ;
Goudsmit, J .
AIDS, 1998, 12 (13) :1591-1600
[20]  
DINTZIS RZ, 1983, J IMMUNOL, V131, P2196