Endogenous small interfering RNAs in animals

被引：260

作者：

Okamura, Katsutomo ^{[1
]}

Lai, Eric C. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Dev Biol, Rockefeller Res Labs 521, New York, NY 10065 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2479

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice. These findings suggest broad and possibly conserved roles for endogenous RNA interference in regulating host-gene expression and transposable element transcripts. They also raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.

引用

页码：673 / 678

页数：6

共 71 条

[1] The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race [J].

Aravin, Alexei A. ;

Hannon, Gregory J. ;

Brennecke, Julius .

SCIENCE, 2007, 318 (5851) :761-764

[2] Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing [J].

Azuma-Mukai, Asuka ;

Oguri, Hideo ;

Mituyama, Toutai ;

Qian, Zhi Rong ;

Asai, Kiyoshi ;

Siomi, Haruhiko ;

Siomi, Mikiko C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (23) :7964-7969

[3] PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C-elegans [J].

Batista, Pedro J. ;

Ruby, J. Graham ;

Claycomb, Julie M. ;

Chiang, Rosaria ;

Fahlgren, Noah ;

Kasschau, Kristin D. ;

Chaves, Daniel A. ;

Gu, Weifeng ;

Vasale, Jessica J. ;

Duan, Shenghua ;

Conte, Darryl, Jr. ;

Luo, Shujun ;

Schroth, Gary P. ;

Carrington, James C. ;

Bartel, David P. ;

Mello, Craig C. .

MOLECULAR CELL, 2008, 31 (01) :67-78

[4]

Brennecke J, 2007, CELL, V128, P1089, DOI 10.1016/j.cell.2007.01.043

[5] RNA sequence analysis defines Dicer's role in mouse embryonic stem cells [J].

Calabrese, J. Mauro ;

Seila, Amy C. ;

Yeo, Gene W. ;

Sharp, Phillip A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (46) :18097-18102

[6] MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline [J].

Carmell, Michelle A. ;

Girard, Angelique ;

van de Kant, Henk J. G. ;

Bourc'his, Deborah ;

Bestor, Timothy H. ;

de Rooij, Dirk G. ;

Hannon, Gregory J. .

DEVELOPMENTAL CELL, 2007, 12 (04) :503-514

[7] Endogenous RNA interference provides a somatic Defense against Drosophila transposons [J].

Chung, Wei-Jen ;

Okamura, Katsutomo ;

Martin, Raquel ;

Lai, Eric C. .

CURRENT BIOLOGY, 2008, 18 (11) :795-802

[8] An endogenous small interfering RNA pathway in Drosophila [J].

Czech, Benjamin ;

Malone, Colin D. ;

Zhou, Rui ;

Stark, Alexander ;

Schlingeheyde, Catherine ;

Dus, Monica ;

Perrimon, Norbert ;

Kellis, Manolis ;

Wohlschlegel, James A. ;

Sachidanandam, Ravi ;

Hannon, Gregory J. ;

Brennecke, Julius .

NATURE, 2008, 453 (7196) :798-U7

[9] Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline [J].

Das, Partha P. ;

Bagijn, Marloes P. ;

Goldstein, Leonard D. ;

Woolford, Julie R. ;

Lehrbach, Nicolas J. ;

Sapetschnig, Alexandra ;

Buhecha, Heeran R. ;

Gilchrist, Michael J. ;

Howe, Kevin L. ;

Stark, Rory ;

Matthewss, Nik ;

Berezilkov, Eugene ;

Ketting, Ren F. ;

Tavare, Simon ;

Miska, Eric A. .

MOLECULAR CELL, 2008, 31 (01) :79-90

[10] miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis [J].

Deng, W ;

Lin, HF .

DEVELOPMENTAL CELL, 2002, 2 (06) :819-830

← 1 2 3 4 5 6 7 8 →