Endogenous small interfering RNAs in animals

被引：262

作者：

Okamura, Katsutomo ^{[1
]}

Lai, Eric C. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Dev Biol, Rockefeller Res Labs 521, New York, NY 10065 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2479

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice. These findings suggest broad and possibly conserved roles for endogenous RNA interference in regulating host-gene expression and transposable element transcripts. They also raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.

引用

页码：673 / 678

页数：6

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