Solid-phase synthesis of benzoxazoles via Mitsunobu reaction

被引：43

作者：

Wang, FJ

Hauske, JR

机构：

[1] Department of Drug Discovery, Sepracor Inc., Marlborough, MA 01752

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(97)01527-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Amidophenol attached to a solid support can be converted corresponding benzoxazole by treatment with triphenylphosphine and azodicarboxylate in THF at room temperature in high yield and purity. (C) 1997 Elsevier Science Ltd.

引用

页码：6529 / 6532

页数：4

共 36 条

[31]

ORJALES A, 1995, J HETEROCYCLIC CHEM, V32, P707

[32] A NEW CHIRAL AUXILIARY FOR ASYMMETRIC THERMAL-REACTIONS - HIGH STEREOCONTROL IN RADICAL-ADDITION, ALLYLATION, AND ANNULATION REACTIONS [J].

STACK, JG ;

CURRAN, DP ;

GEIB, SV ;

REBEK, J ;

BALLESTER, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (18) :7007-7018

[33] SYNTHESIS OF BOXAZOMYCIN B AND RELATED ANALOGS [J].

SUTO, MJ ;

TURNER, WR .

TETRAHEDRON LETTERS, 1995, 36 (40) :7213-7216

[34] COMBINATORIAL SYNTHESIS - THE DESIGN OF COMPOUND LIBRARIES AND THEIR APPLICATION TO DRUG DISCOVERY [J].

TERRETT, NK ;

GARDNER, M ;

GORDON, DW ;

KOBYLECKI, RJ ;

STEELE, J .

TETRAHEDRON, 1995, 51 (30) :8135-8173

[35] Synthesis and applications of small molecule libraries [J].

Thompson, LA ;

Ellman, JA .

CHEMICAL REVIEWS, 1996, 96 (01) :555-600

[36] ISOLATION AND CHARACTERIZATION OF A NOVEL POLYETHER ANTIBIOTIC OF THE PYRROLETHER CLASS, ANTIBIOTIC-X-14885A [J].

WESTLEY, JW ;

LIU, CM ;

BLOUNT, JF ;

SELLO, LH ;

TROUPE, N ;

MILLER, PA .

JOURNAL OF ANTIBIOTICS, 1983, 36 (10) :1275-1278

← 1 2 3 4 →