Templated amplification of a naphthalenediimide-based receptor from a donor-acceptor dynamic combinatorial library in water

被引:48
作者
Au-Yeung, Ho Yu [1 ]
Pengo, Paolo [1 ]
Pantos, G. Dan [1 ]
Otto, Sijbren [1 ]
Sanders, Jeremy K. M. [1 ]
机构
[1] Univ Cambridge, Univ Chem Lab, Cambridge CB2 1EW, England
基金
英国工程与自然科学研究理事会;
关键词
CHEMISTRY; MOLECULES;
D O I
10.1039/b816979a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report a dynamic combinatorial library that, upon binding of an electronically-complementary guest, produces in high yield a tetrameric receptor with. at hydrophobic, electron-deficient surfaces and flexible, water-soluble disulfide-containing linkers; analysis of the dependence of library composition on template concentration gives insight into the binding behaviours of the species involved.
引用
收藏
页码:419 / 421
页数:3
相关论文
共 18 条
[1]   Interlocked and intertwined structures and superstructures [J].
Amabilino, DB ;
Stoddart, JF .
CHEMICAL REVIEWS, 1995, 95 (08) :2725-2828
[2]   Molecular amplification of two different receptors using diastereomeric templates [J].
Bulos, Fernando ;
Roberts, Sarah L. ;
Furlan, Ricardo L. E. ;
Sanders, Jeremy K. M. .
CHEMICAL COMMUNICATIONS, 2007, (29) :3092-3093
[3]   Dynamic combinatorial chemistry [J].
Corbett, Peter T. ;
Leclaire, Julien ;
Vial, Laurent ;
West, Kevin R. ;
Wietor, Jean-Luc ;
Sanders, Jeremy K. M. ;
Otto, Sijbren .
CHEMICAL REVIEWS, 2006, 106 (09) :3652-3711
[4]   Diastereoselective amplification of an induced-fit receptor from a dynamic combinatorial library [J].
Corbett, PT ;
Tong, LH ;
Sanders, JKM ;
Otto, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (25) :8902-8903
[5]   1H NMR investigation of solvent effects in aromatic stacking interactions [J].
Cubberley, MS ;
Iverson, BL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (31) :7560-7563
[6]   Dynamic combinatorial chemistry: The unexpected choice of receptors by guest molecules [J].
de Bruin, B ;
Hauwert, P ;
Reek, JNH .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (17) :2660-2663
[7]   Macrocyclization and molecular interlocking via Mitsunobu alkylation:: Highlighting the role of C-H•••O interactions in templating [J].
Hansen, JG ;
Feeder, N ;
Hamilton, DG ;
Gunter, MJ ;
Becher, J ;
Sanders, JKM .
ORGANIC LETTERS, 2000, 2 (04) :449-452
[8]  
HOUK KN, 1999, J AM CHEM SOC, V23, P897
[9]   Dynamic combinatorial libraries of metalloporphyrins: templated amplification of disulfide-linked oligomers [J].
Kieran, AL ;
Bond, AD ;
Belenguer, AM ;
Sanders, JKM .
CHEMICAL COMMUNICATIONS, 2003, (21) :2674-2675
[10]   Dynamic combinatorial chemistry: on the road to fulfilling the promise [J].
Ladame, Sylvain .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (02) :219-226