Vascular endothelial growth factors (VEGFs) and stroke

被引：279

作者：

Greenberg, David A. ^{[1
]}

Jin, Kunlin ^{[1
,2
]}

机构：

[1] Buck Inst Res Aging, Novato, CA 94945 USA

[2] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Vascular endothelial growth factor; Stroke; Ischemia; Neuroprotection; Neurogenesis; Angiogenesis; FOCAL CEREBRAL-ISCHEMIA; NEURAL STEM-CELLS; BLOOD-BRAIN-BARRIER; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; STIMULATES AXONAL OUTGROWTH; HYPOPERFUSED RAT-BRAIN; PROGENITOR CELLS; GENE-EXPRESSION; NERVOUS-SYSTEM; IN-VITRO;

D O I：

10.1007/s00018-013-1282-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

引用

收藏

页码：1753 / 1761

页数：9

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