The effect of docosahexaenoic acid on the electroretinogram of the guinea pig

被引:93
作者
Weisinger, HS
Vingrys, AJ
Sinclair, AJ
机构
[1] ROYAL MELBOURNE INST TECHNOL,DEPT FOOD SCI,MELBOURNE,VIC 3001,AUSTRALIA
[2] UNIV MELBOURNE,DEPT OPTOMETRY & VIS SCI,PARKVILLE,VIC 3052,AUSTRALIA
关键词
D O I
10.1007/BF02522413
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, is found in consistently high concentrations in the retinae of mammals, yet its role in vision remains unclear. In this study, a mammalian model of variable retinal DHA concentration has been developed, such that the retinal phospholipids of guinea pigs contained between 2.5 and 30.8% DHA. Visual function was assessed using full-field flash electroretinography, over a range of exposure levels spanning six log units. Trend analysis indicated that retinal function was altered by the tissue DHA level, and was described by a second-order polynomial ''inverted U-shaped'' function. The results suggested that although some amount of DHA is essential for normal retinal function, increases in the DHA level past an optimal amount, found to be 19%, provided diminishing returns. In this study, manipulation of the retinal DHA level accounted for 21-35% of the electroretinographic variability.
引用
收藏
页码:65 / 70
页数:6
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