The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes

被引：112

作者：

Alvarez-Venegas, R

Sadder, M

Hlavacka, A

Baluska, F

Xia, YN

Lu, GQ

Firsov, A

Sarath, G

Moriyama, H

Dubrovsky, JG

Avramova, Z ^{[1
]}

机构：

[1] Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA

[2] Univ Bonn, Inst Bot, Dept Plant Cell Biol, D-53115 Bonn, Germany

[3] Univ Nebraska, Ctr Biotechnol, Genom Core Res Facil, Lincoln, NE 68588 USA

[4] Univ Nebraska, Ctr Biotechnol, Bioinformat Core Res Facil, Lincoln, NE 68588 USA

[5] Univ Nebraska, USDA, Agr Res Serv Unit, Lincoln, NE 68583 USA

[6] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA

[7] Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62250, Morelos, Mexico

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 15期

关键词：

epigenetic regulation; lipid signaling;

D O I：

10.1073/pnas.0600944103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.

引用

页码：6049 / 6054

页数：6

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