Efficient Phosphodiester Cleaving Nanozymes Resulting from Multivalency and Local Medium Polarity Control

被引：97

作者：

Diez-Castellnou, Marta ^{[1
]}

Mancin, Fabrizio ^{[1
]}

Scrimin, Paolo ^{[1
]}

机构：

[1] Univ Padua, Dept Chem Sci, I-35131 Padua, Italy

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 04期

基金：

欧盟第七框架计划;

关键词：

DINUCLEAR ZN(II) COMPLEX; RNA MODELS; CLEAVAGE; DNA; CATALYSIS; WATER; HYDROLYSIS; NANOPARTICLES; MECHANISM; ENZYMES;

D O I：

10.1021/ja411969e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The self-organization of Zn(II) complexes on the surface of 1.6-nm diameter gold nanoparticles (nanozymes) allows the spontaneous formation of multiple bimetallic catalytic sites capable to promote the cleavage of a RNA model substrate. We show that by tuning the structure of the nanoparticle-coating monolayer, it is possible to decrease the polarity of the reaction site, and this in turn generates remarkable increments of the cleavage efficiency.

引用

收藏

页码：1158 / 1161

页数：4

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