Investigation of noncovalent complexes between β-cyclodextrin and polyamide acids containing N-methylpyrrole and N-methylimidazole by electrospray ionization mass spectrometry

被引：10

作者：

Li, HH ^{[1
]}

Zhou, J ^{[1
]}

Tang, FL ^{[1
]}

Yuan, G ^{[1
]}

机构：

[1] Peking Univ, Dept Biol Chem, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2006年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.jasms.2005.08.011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrospray ionization (ESI) mass spectrometry was utilized to investigate noncovalent complexes between beta-cyclodextrin (beta-CD) and five novel polyamide acids containing N-methylpyrrole and N-methylimidazole. The 1:1 binding mode was specified by examining the binding stoichiometry from ESI mass spectra. It found that polyamide acids with P-CD have binding affinities in the order: ImImIm beta COOH > ImPyIm beta COOH > ImPyPy beta COOH > PyPyPy beta COOH > NO(2)PyPyPy beta COOH. The method gives, simultaneously, the binding constants between P-CD and polyamide acids based on a novel linear equation.

引用

收藏

页码：9 / 14

页数：6

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