Translational regulation as a novel mechanism for the development of cellular drug resistance

被引：19

作者：

Schmitz, JC

Liu, J

Lin, XK

Chen, TM

Yan, W

Tai, NW

Gollerkeri, A

Chu, E

机构：

[1] Yale Univ, Sch Med, Yale Canc Ctr, Dept Med & Pharmacol, New Haven, CT USA

[2] VA CT Healthcare Syst, VA CT Canc Ctr, New Haven, CT USA

来源：

CANCER AND METASTASIS REVIEWS | 2001年 / 20卷 / 1-2期

关键词：

thymidylate synthase; dihydrofolate reductase; p53 translational regulation; drug resistance;

D O I：

10.1023/A:1013100306315

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance.

引用

收藏

页码：33 / 41

页数：9

相关论文

共 69 条

[1] DNA-POLYMERASE OF BACTERIOPHAGE-T4 IS AN AUTOGENOUS TRANSLATIONAL REPRESSOR [J].

ANDRAKE, M ;

GUILD, N ;

HSU, T ;

GOLD, L ;

TUERK, C ;

KARAM, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :7942-7946

[2] THE INTRACELLULAR CONTENT OF DIHYDROFOLATE-REDUCTASE - POSSIBILITIES FOR CONTROL AND IMPLICATIONS FOR CHEMOTHERAPY [J].

BASTOW, KF ;

PRABHU, R ;

CHENG, YC .

ADVANCES IN ENZYME REGULATION, 1984, 22 :15-26

[3] NUCLEOTIDE SEQUENCE AT BINDING-SITE FOR COAT PROTEIN ON RNA OF BACTERIOPHAGE-R17 [J].

BERNARDI, A ;

SPAHR, PF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (10) :3033-+

[4]

BERTINO JR, 1965, CLIN PHARMACOL THER, V6, P763

[5] STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES .4. TETRAHYDROFOLATE-DEPENDENT ENZYME SYSTEMS AND DIHYDROFOLIC REDUCTASE [J].

BERTINO, JR ;

HUENNEKENS, FM ;

GABRIO, BW ;

FREEMAN, M ;

SILBER, R ;

ALENTY, A ;

ALBRECHT, M .

JOURNAL OF CLINICAL INVESTIGATION, 1963, 42 (12) :1899-&

[6]

BONNEY RJ, 1975, CANCER RES, V35, P1950

[7] Disruption of p53 in human cancer cells alters the responses to therapeutic agents [J].

Bunz, F ;

Hwang, PM ;

Torrance, C ;

Waldman, T ;

Zhang, YG ;

Dillehay, L ;

Williams, J ;

Lengauer, C ;

Kinzler, KW ;

Vogelstein, B .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (03) :263-269

[8] Requirement for p53 and p21 to sustain G2 arrest after DNA damage [J].

Bunz, F ;

Dutriaux, A ;

Lengauer, C ;

Waldman, T ;

Zhou, S ;

Brown, JP ;

Sedivy, JM ;

Kinzler, KW ;

Vogelstein, B .

SCIENCE, 1998, 282 (5393) :1497-1501

[9] SEQUENCE-SPECIFIC INTERACTION OF R17-COAT PROTEIN WITH ITS RIBONUCLEIC-ACID BINDING-SITE [J].

CAREY, J ;

CAMERON, V ;

DEHASETH, PL ;

UHLENBECK, OC .

BIOCHEMISTRY, 1983, 22 (11) :2601-2610

[10] THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE [J].

CARRERAS, CW ;

SANTI, DV .

ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 :721-762

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