Translational regulation as a novel mechanism for the development of cellular drug resistance

被引：19

作者：

Schmitz, JC

Liu, J

Lin, XK

Chen, TM

Yan, W

Tai, NW

Gollerkeri, A

Chu, E

机构：

[1] Yale Univ, Sch Med, Yale Canc Ctr, Dept Med & Pharmacol, New Haven, CT USA

[2] VA CT Healthcare Syst, VA CT Canc Ctr, New Haven, CT USA

来源：

CANCER AND METASTASIS REVIEWS | 2001年 / 20卷 / 1-2期

关键词：

thymidylate synthase; dihydrofolate reductase; p53 translational regulation; drug resistance;

D O I：

10.1023/A:1013100306315

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance.

引用

页码：33 / 41

页数：9

共 69 条

[61] DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 [J].