Ancient human DNA

被引：20

作者：

Kirsanow, Karola ^{[1
]}

Burger, Joachim ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Anthropol, D-55128 Mainz, Germany

来源：

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2012年 / 194卷 / 01期

关键词：

Palaeogenetics; Hominin; Contamination; Ancient DNA; Sequence artefacts; Next generation sequencing; Authenticity; MITOCHONDRIAL GENOME SEQUENCE; AMINO-ACID RACEMIZATION; CLOVIS HUMAN COPROLITES; LACTASE-PERSISTENCE; MISCODING LESIONS; NEANDERTHAL GENOME; POPULATION; PATTERNS; BONE; MTDNA;

D O I：

10.1016/j.aanat.2011.11.002

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The contribution of palaeogenetic data to the study of various aspects of hominin biology and evolution has been significant, and has the potential to increase substantially with the widespread implementation of next generation sequencing techniques. Here we discuss the present state-of-the-art of ancient human DNA analysis and the characteristics of hominin aDNA that make sequence validation particularly complex. A brief overview of the development of anthropological palaeogenetic analysis is given to illustrate the technical challenges motivating recent technological advancements. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：121 / 132

页数：12

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