The complete mitochondrial DNA genome of an unknown hominin from southern Siberia

被引：464

作者：

Krause, Johannes ^{[1
]}

Fu, Qiaomei ^{[1
]}

Good, Jeffrey M. ^{[2
]}

Viola, Bence ^{[1
,3
]}

Shunkov, Michael V. ^{[4
]}

Derevianko, Anatoli P. ^{[4
]}

Paeaebo, Svante ^{[1
]}

机构：

[1] Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany

[2] Univ Montana, Div Biol Sci, Missoula, MT 59812 USA

[3] Univ Vienna, Dept Anthropol, A-1090 Vienna, Austria

[4] Russian Acad Sci, Siberian Branch, Inst Archaeol & Ethnog, Paleolith Dept, RU-630090 Novosibirsk 17, Russia

来源：

NATURE | 2010年 / 464卷 / 7290期

关键词：

SEQUENCE; ORIGIN; FLORES; AGE;

D O I：

10.1038/nature08976

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

With the exception of Neanderthals, from which DNA sequences of numerous individuals have now been determined(1), the number and genetic relationships of other hominin lineages are largely unknown. Here we report a complete mitochondrial (mt) DNA sequence retrieved from a bone excavated in 2008 in Denisova Cave in the Altai Mountains in southern Siberia. It represents a hitherto unknown type of hominin mtDNA that shares a common ancestor with anatomically modern human and Neanderthal mtDNAs about 1.0 million years ago. This indicates that it derives from a hominin migration out of Africa distinct from that of the ancestors of Neanderthals and of modern humans. The stratigraphy of the cave where the bone was found suggests that the Denisova hominin lived close in time and space with Neanderthals as well as with modern humans(2-4).

引用

页码：894 / 897

页数：4

共 29 条

[1] Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA [J].

Andrews, RM ;

Kubacka, I ;

Chinnery, PF ;

Lightowlers, RN ;

Turnbull, DM ;

Howell, N .

NATURE GENETICS, 1999, 23 (02) :147-147

[2]

Bermudez De Castro J. M., 1997, Science (Washington D C), V276, P1392, DOI 10.1126/science.276.5317.1392

[3] The fossil palynoflora, geological age, and climatostratigraphy of the earliest deposits of the Karama site (Early Paleolithic, Altai Mountains) [J].

Bolikhovskaya, N. S. ;

Derevyanko, A. P. ;

Shun'kov, M. V. .

PALEONTOLOGICAL JOURNAL, 2006, 40 (Suppl 5) :S558-S566

[4] Patterns of damage in genomic DNA sequences from a Neandertal [J].

Briggs, Adrian W. ;

Stenzel, Udo ;

Johnson, Philip L. F. ;

Green, Richard E. ;

Kelso, Janet ;

Pruefer, Kay ;

Meyer, Matthias ;

Krause, Johannes ;

Ronan, Michael T. ;

Lachmann, Michael ;

Paeaebo, Svante .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (37) :14616-14621

[5] Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA [J].

Briggs, Adrian W. ;

Stenzel, Udo ;

Meyer, Matthias ;

Krause, Johannes ;

Kircher, Martin ;

Paeaebo, Svante .

NUCLEIC ACIDS RESEARCH, 2010, 38 (06) :e87.1-e87.12

[6] Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes [J].

Briggs, Adrian W. ;

Good, Jeffrey M. ;

Green, Richard E. ;

Krause, Johannes ;

Maricic, Tomislav ;

Stenzel, Udo ;

Lalueza-Fox, Carles ;

Rudan, Pavao ;

Brajkovic, Dejana ;

Kucan, Zeljko ;

Gusic, Ivan ;

Schmitz, Ralf ;

Doronichev, Vladimir B. ;

Golovanova, Liubov V. ;

de la Rasilla, Marco ;

Fortea, Javier ;

Rosas, Antonio ;

Paeaebo, Svante .

SCIENCE, 2009, 325 (5938) :318-321

[7] Novel high-resolution characterization of ancient DNA reveals C>U-type base modification events as the sole cause of post mortem miscoding lesions [J].

Brotherton, Paul ;

Endicott, Phillip ;

Sanchez, Juan J. ;

Beaumont, Mark ;

Barnett, Ross ;

Austin, Jeremy ;

Cooper, Alan .

NUCLEIC ACIDS RESEARCH, 2007, 35 (17) :5717-5728

[8] A new small-bodied hominin from the Late Pleistocene of Flores, Indonesia [J].

Brown, P ;

Sutikna, T ;

Morwood, MJ ;

Soejono, RP ;

Jatmiko ;

Saptomo, EW ;

Due, RA .

NATURE, 2004, 431 (7012) :1055-1061

[9] A 28,000 Years Old Cro-Magnon mtDNA Sequence Differs from All Potentially Contaminating Modern Sequences [J].

Caramelli, David ;

Milani, Lucio ;

Vai, Stefania ;

Modi, Alessandra ;

Pecchioli, Elena ;

Girardi, Matteo ;

Pilli, Elena ;

Lari, Martina ;

Lippi, Barbara ;

Ronchitelli, Annamaria ;

Mallegni, Francesco ;

Casoli, Antonella ;

Bertorelle, Giorgio ;

Barbujani, Guido .

PLOS ONE, 2008, 3 (07)

[10]

Derevianko AP, 2008, ARCHAEOL ETHNOL ANTH, V34, P13, DOI 10.1016/j.aeae.2008.07.002

← 1 2 3 →