Studies on the interaction of phosphate anions with N-functionalised polyaza[n] paracyclophanes:: the role of N-methylation

被引：27

作者：

Albelda, MT

Frías, JC

García-España, E

Luis, SV

机构：

[1] Univ Jaume 1, Dept Quim Inorgan & Organ, UA Mat Organ Avanzados, CSIC, Castellon de La Plana, Spain

[2] Univ Valencia, Dept Quim Inorgan, Valencia 46100, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 06期

关键词：

D O I：

10.1039/b315717b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and interaction of N, N', N", N'''-tetramethyl- 2,6,9,13-tetraaza[14] paracyclophanes (B323Me(4)) with nucleotides and inorganic phosphates is described. An easy methodology is used to de. ne thermodynamic selectivity. The interaction of B323Me4 and ATP has been monitored by H-1, P-31 NMR and by molecular mechanics, ruling out the possibility of the participation of pi-stacking interactions. Results show that N-methylation is accompanied by a strong increase in the interaction of the resulting macrocycle with ATP.

引用

页码：816 / 820

页数：5

共 49 条

[31] A NONCONSERVATIVE SERINE TO CYSTEINE MUTATION IN THE SULFATE-BINDING PROTEIN, A TRANSPORT RECEPTOR [J].