Recent developments in combinatorial organic synthesis

被引：59

作者：

Ganesan, A ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 01期

关键词：

D O I：

10.1016/S1359-6446(02)00002-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The level of sophistication of combinatorial synthesis continues to increase at a heady pace. Fairly complex target molecules are now being assembled combinatorially using a broad palette of organic reactions both in solution- and solid-phase. This review highlights academic and industrial examples of combinatorial synthesis published within the last year. Recent advances in small-molecule synthesis are outlined, ranging from simple acyclic scaffolds to complex natural products.

引用

页码：47 / 55

页数：9

共 26 条

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Aberle, NS ;

Ganesan, A ;

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[2] Solid-phase synthesis of 4-triphenylphosphoranylidene-4,5-dihydropyrazol-5-ones, 4-aminocarbonyl-pyrroles, 4-methoxy-1H-pyrazol-5(2H)-ones and 2-thiazolin-4-ones from polymer-bound 1,2-diaza-1,3-butadienes [J].

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TETRAHEDRON LETTERS, 2001, 42 (11) :2063-2068

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (03) :398-408

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (16) :2169-2171

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Nicolaou, KC ;

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