Parallel modification of tropane alkaloids

被引：11

作者：

Aberle, NS

Ganesan, A

Lambert, JN ^{[1
]}

Saubern, S

Smith, R

机构：

[1] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

[2] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[3] CSIRO, Clayton S, Vic 3169, Australia

[4] Phytex Australia Pty Ltd, Peakhurst 2210, Australia

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)00028-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various tropane alkaloids have been prepared by structural modification of the readily available natural product, scopolamine 1. Reaction of isocyanates with 6,7-dehydrotropine 5 provided a number of urethanes 6a-e. Reductive amination of tropinone 7 and subsequent reaction with isocyanates provided ureas 9a-f. Mitsunobu inversion of the C-3 alcohol of tropine 10 afforded the epimeric ester 11. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1975 / 1977

页数：3

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