The cluster glycoside effect

被引：1345

作者：

Lundquist, JJ ^{[1
]}

Toone, EJ ^{[1
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27708 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 02期

关键词：

D O I：

10.1021/cr000418f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cluster glycoside effect considering the construction of multivalent saccharides, the various assays used to evaluate protein-carbohydrate binding, the behavior of multivalent ligands in these assays, and the molecular basis for the observed activity is reviewed. Its objectives are to provide a framework in which to consider reported activities of multivalent oligosaccharide epitopes. In turn, this framework is said to provide the reader a molecular model of association that will aid the design of new molecules with predictable and defined activities.

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页码：555 / 578

页数：24

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