The cluster glycoside effect

被引:1345
作者
Lundquist, JJ [1 ]
Toone, EJ [1 ]
机构
[1] Duke Univ, Dept Chem, Durham, NC 27708 USA
关键词
D O I
10.1021/cr000418f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The cluster glycoside effect considering the construction of multivalent saccharides, the various assays used to evaluate protein-carbohydrate binding, the behavior of multivalent ligands in these assays, and the molecular basis for the observed activity is reviewed. Its objectives are to provide a framework in which to consider reported activities of multivalent oligosaccharide epitopes. In turn, this framework is said to provide the reader a molecular model of association that will aid the design of new molecules with predictable and defined activities.
引用
收藏
页码:555 / 578
页数:24
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