An efficient chemoenzymatic access to chiral 3,7-diazabicyclo[3.3.1]nonane derivatives

被引：14

作者：

Danieli, B ^{[1
]}

Lesma, G ^{[1
]}

Passarella, D ^{[1
]}

Silvani, A ^{[1
]}

Viviani, N ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, CNR, Ctr Studio Sostanze Organ Nat, I-20133 Milan, Italy

来源：

TETRAHEDRON | 1999年 / 55卷 / 40期

关键词：

alkaloids; aminals; bicyclic heterocyclic compounds; enzyme reactions;

D O I：

10.1016/S0040-4020(99)00674-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiopure 3,7-diazabicyclo[3.3.1]nonane derivatives 4 and 5, potential precursors of quinolizidine alkaloids, were synthesised in high yields, starting from the biocatalytic asymmetrization of sigma-symmetric 3,5-disubstituted piperidines. Their application to the total synthesis of the new pharmacologically active compounds 3 are also described. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：11871 / 11878

页数：8

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