Annonaceous acetogenins of the seeds from Annona muricata

被引：13

作者：

Li, DY

Yu, JG ^{[1
]}

Zhu, JX

Yu, DL

Luo, XZ

Sun, L

Yang, SL

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China

[2] Beijing Union Med Coll, Beijing 100094, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2001年 / 3卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Annona muricata; annonaceae; acetogenins; muricatenol; 2,4-cis-gigantetrocinone; 2,4-trans-gigantetrocinone; 2,4-trans-isoannonacin-10-one; 2,4-trans-isoannonacin; antitumor activities;

D O I：

10.1080/10286020108040366

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Muricatenol (1) is a new C-37 non-THF ring acetogenin with four hydroxyls and one isolated double bond in the long aliphatic chain. 2,4-cis-Gigantetrocinone (2) and 2,4-transgigantetrocinone (3) have been isolated as their acetates by preparative TLC. 2,4-trans-Isoannonacin-10-one (4) and 2,4-trans-isoannonacin (5) have been isolated as only 2,4-trans-form for the first time (no cis-form). Also four known acetogenins, gigantetrocin-A (6), gigantetrocin-B (7), annomontacin (8), gigantetronenin (9) and a mixture of N-fatty acyl tryptamines have been isolated (10). Their structures have been established on the basis of spectral analyses. The CHCl3 fraction of the seeds showed strong antitumor activities.

引用

页码：267 / 276

页数：10