A new region of conservation is defined between human and mouse X chromosomes

被引：15

作者：

Dinulos, MB

Bassi, MT

Rugarli, EI

Chapman, V

Ballabio, A

Disteche, CM

机构：

[1] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195

[2] UNIV SIENA,DEPT BIOL MOLEC,I-53100 SIENA,ITALY

[3] TELETHON INST GENET & MED,MILAN,ITALY

[4] ROSWELL PK CANC INST,DEPT MOLEC & CELL BIOL,BUFFALO,NY 14263

来源：

GENOMICS | 1996年 / 35卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0347

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Comparative mapping of the X chromosome in eutherian mammals has revealed distinct regions of conservation as well as evolutionary rearrangements between human and mouse. Recently, we and others mapped the murine homologue of CLCN4 (Chloride channel 4) to band F4 of the X chromosome in Mus spretus but to chromosome 7 in laboratory strains. We now report the mapping of the murine homologues of APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), two genes that are located on the human X chromosome at band p22.3 and in close proximity to CLCN4, Interestingly, Oa1 and Apxl map to bands F2-F3 in both IM. spretus and the laboratory strain C57BL/6J, defining a new rearrangement between human and mouse X chromosomes. (C) 1996 Academic Press, Inc.

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页码：244 / 247

页数：4

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