Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: A review

被引：162

作者：

Chen, Fei ^{[1
]}

Hu, Shen-Jiang ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Cardiol, Hangzhou 310003, Zhejiang, Peoples R China

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2012年 / 26卷 / 02期

关键词：

miR-34a; Cell Cycle; Differentiation; Apoptosis; ONCOGENE-INDUCED SENESCENCE; P53; TUMOR-SUPPRESSOR; IDENTIFIES MIR-34A; DOWN-REGULATION; CANCER; EXPRESSION; NEUROBLASTOMA; ACTIVATION; REGULATOR; PROLIFERATION;

D O I：

10.1002/jbt.20412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor suppressor gene p53 was shown to directly regulate the expression of microRNA-34a (miR-34a). miR-34a regulates a plethora of target proteins, which are involved in cell cycle, apoptosis, differentiation, and cellular development.miR-34a resides in the region of chromosome 1p36.23, which is commonly deleted in many tumor types, while it results in the loss expression of miR-34a. The promoters of the miR-34a gene subject to inactivation by CpG methylation also induce the loss expression of miR-34a. Ectopic miR-34a expression induces apoptosis, cell cycle arrest, and differentiation or reduces migration. This review summarizes the progress regarding the role of miR-34a in cell cycle, differentiation, and apoptosis. (c) 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:7986 2012; View this article online at . DOI 10.1002/jbt.20412

引用

页码：79 / 86

页数：8

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