Synthesis and cardiotonic activity of imidazo[2,1-b]thiazoles bearing a lactam ring

被引:61
作者
Andreani, A [1 ]
Rambaldi, M [1 ]
Leoni, A [1 ]
Locatelli, A [1 ]
Bossa, R [1 ]
Chiericozzi, M [1 ]
Galatulas, I [1 ]
Salvatore, G [1 ]
机构
[1] UNIV MILAN,DIPARTIMENTO FARMACOL,CTM,I-20129 MILAN,ITALY
关键词
imidazo[2,1-b]thiazole; lactam 2,5-dimethoxyphenyl; cardiotonic activity;
D O I
10.1016/0223-5234(96)89164-1
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This paper describes the synthesis of 6-substituted imidazo[2,1-b] thiazoles with a lactam ring connected, by means of a methine group, to the 5-position. The pharmacological results show that interesting cardiotonic activity is obtained when the lactam ring is pseudothiohydantoin (8) or barbituric acid (9). Even the substituent at position 6 plays an important role in the pharmacological behavior of these derivatives. The following activity rank order was observed: phenyl > methyl > chlorine.
引用
收藏
页码:383 / 387
页数:5
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