Synthesis and cardiotonic activity of imidazo[2,1-b]thiazoles bearing a lactam ring

被引：62

作者：

Andreani, A ^{[1
]}

Rambaldi, M ^{[1
]}

Leoni, A ^{[1
]}

Locatelli, A ^{[1
]}

Bossa, R ^{[1
]}

Chiericozzi, M ^{[1
]}

Galatulas, I ^{[1
]}

Salvatore, G ^{[1
]}

机构：

[1] UNIV MILAN,DIPARTIMENTO FARMACOL,CTM,I-20129 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 31卷 / 05期

关键词：

imidazo[2,1-b]thiazole; lactam 2,5-dimethoxyphenyl; cardiotonic activity;

D O I：

10.1016/0223-5234(96)89164-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper describes the synthesis of 6-substituted imidazo[2,1-b] thiazoles with a lactam ring connected, by means of a methine group, to the 5-position. The pharmacological results show that interesting cardiotonic activity is obtained when the lactam ring is pseudothiohydantoin (8) or barbituric acid (9). Even the substituent at position 6 plays an important role in the pharmacological behavior of these derivatives. The following activity rank order was observed: phenyl > methyl > chlorine.

引用

页码：383 / 387

页数：5

共 14 条

[1]

ANDREANI A, 1986, EUR J MED CHEM, V21, P55

[2] SYNTHESIS AND CARDIOTONIC ACTIVITY OF 2-INDOLINONES BEARING PYRIDYL GROUPS [J].