Epibatidine structure-activity relationships

被引：63

作者：

Carroll, FI ^{[1
]}

机构：

[1] Res Triangle Inst, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 08期

关键词：

epibatidine; nicotine; SAR; nicotinic receptors; nAChRs;

D O I：

10.1016/j.bmcl.2004.02.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Epibatidine is a potent but nonselective nAChR agonist. Its biological effects appear to be mediated largely by alpha4beta2 nAChRs. Surprisingly, only a limited number of epibatidine analogues have been synthesized and evaluated in in vitro assays. Even fewer analogues have received in vivo pharmacological evaluation. In this paper, SAR studies directed toward epibatidine analogues will be reviewed. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：1889 / 1896

页数：8

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