Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States

被引：15

作者：

Burke, Rachel M. ^{[1
,2
]}

Balter, Sharon ^{[1
,3
]}

Barnes, Emily ^{[1
,3
]}

Barry, Vaughn ^{[1
,2
]}

Bartlett, Karri ^{[1
,4
]}

Beer, Karlyn D. ^{[1
,2
]}

Benowitz, Isaac ^{[1
,2
]}

Biggs, Holly M. ^{[1
,2
]}

Bruce, Hollianne ^{[1
,5
]}

Bryant-Genevier, Jonathan ^{[1
,2
]}

Cates, Jordan ^{[1
,2
]}

Chatham-Stephens, Kevin ^{[1
,2
]}

Chea, Nora ^{[1
,2
]}

Chiou, Howard ^{[1
,2
,3
]}

Christiansen, Demian ^{[1
,6
]}

Chu, Victoria T. ^{[1
,2
]}

Clark, Shauna ^{[1
,7
]}

Cody, Sara H. ^{[1
,8
]}

Cohen, Max ^{[1
,2
]}

Conners, Erin E. ^{[1
,2
]}

Dasari, Vishal ^{[1
,2
]}

Dawson, Patrick ^{[1
,2
]}

DeSalvo, Traci ^{[1
,9
]}

Donahue, Matthew ^{[1
,2
]}

Dratch, Alissa ^{[1
,10
]}

Duca, Lindsey ^{[1
,2
]}

Duchin, Jeffrey ^{[1
,7
]}

Dyal, Jonathan W. ^{[1
,2
]}

Feldstein, Leora R. ^{[1
,2
]}

Fenstersheib, Marty ^{[1
,11
]}

Fischer, Marc ^{[1
,2
]}

Fisher, Rebecca ^{[1
,3
]}

Foo, Chelsea ^{[1
,3
]}

Freeman-Ponder, Brandi ^{[1
,2
]}

Fry, Alicia M. ^{[1
,2
]}

Gant, Jessica ^{[1
,12
]}

Gautom, Romesh ^{[1
,13
]}

Ghinai, Isaac ^{[1
,2
,14
]}

Gounder, Prabhu ^{[1
,3
]}

Grigg, Cheri T. ^{[1
,2
]}

Gunzenhauser, Jeffrey ^{[1
,3
]}

Hall, Aron J. ^{[1
,2
]}

Han, George S. ^{[1
,8
]}

Haupt, Thomas ^{[1
,9
]}

Holshue, Michelle ^{[1
,2
,13
]}

Hunter, Jennifer ^{[1
,2
]}

Ibrahim, Mireille B. ^{[1
,3
]}

Jacobs, Max W. ^{[1
,3
]}

Jarashow, M. Claire ^{[1
,3
]}

Joshi, Kiran ^{[1
,6
]}

机构：

[1] COVID 19 Close Contact Invest Team, Atlanta, GA USA

[2] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

[3] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA

[4] Publ Hlth Madison & Dane Cty, Madison, WI USA

[5] Snohomish Hlth Dist, Everett, WA USA

[6] Cook Cty Dept Publ Hlth, Oak Forest, IL USA

[7] Publ Hlth Seattle King Cty, Seattle, WA USA

[8] Dept Publ Hlth, San Jose, CA USA

[9] Wisconsin Dept Hlth Serv, Madison, WI USA

[10] Orange Cty Healthcare Agcy, Santa Ana, CA USA

[11] San Benito Cty Publ Hlth Serv, Hollister, CA USA

[12] Washington State Publ Hlth Labs, Shoreline, WA USA

[13] Washington State Dept Hlth, Shoreline, WA USA

[14] Chicago Dept Publ Hlth, Chicago, IL USA

[15] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA

[16] Illinois Dept Publ Hlth, Chicago, IL USA

[17] Wyoming Dept Hlth, Cheyenne, WY USA

[18] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA

[19] Maricopa Cty Dept Publ Hlth, Phoenix, AZ USA

来源：

PLOS ONE | 2020年 / 15卷 / 09期

关键词：

TRANSMISSION; INFECTIONS; WASHINGTON;

D O I：

10.1371/journal.pone.0238342

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Coronavirus disease 2019 (COVID-19), the respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China and has since become pandemic. In response to the first cases identified in the United States, close contacts of confirmed COVID-19 cases were investigated to enable early identification and isolation of additional cases and to learn more about risk factors for transmission. Close contacts of nine early travel-related cases in the United States were identified and monitored daily for development of symptoms (active monitoring). Selected close contacts (including those with exposures categorized as higher risk) were targeted for collection of additional exposure information and respiratory samples. Respiratory samples were tested for SARS-CoV-2 by real-time reverse transcription polymerase chain reaction at the Centers for Disease Control and Prevention. Four hundred four close contacts were actively monitored in the jurisdictions that managed the travel-related cases. Three hundred thirty-eight of the 404 close contacts provided at least basic exposure information, of whom 159 close contacts had >= 1 set of respiratory samples collected and tested. Across all actively monitored close contacts, two additional symptomatic COVID-19 cases (i.e., secondary cases) were identified; both secondary cases were in spouses of travel-associated case patients. When considering only household members, all of whom had >= 1 respiratory sample tested for SARS-CoV-2, the secondary attack rate (i.e., the number of secondary cases as a proportion of total close contacts) was 13% (95% CI: 4-38%). The results from these contact tracing investigations suggest that household members, especially significant others, of COVID-19 cases are at highest risk of becoming infected. The importance of personal protective equipment for healthcare workers is also underlined. Isolation of persons with COVID-19, in combination with quarantine of exposed close contacts and practice of everyday preventive behaviors, is important to mitigate spread of COVID-19.

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