MicroRNA function in NK-cell biology

被引：56

作者：

Beaulieu, Aimee M. ^{[1
]}

Bezman, Natalie A. ^{[2
,3
]}

Lee, Jang Eun ^{[4
]}

Matloubian, Mehrdad ^{[4
]}

Sun, Joseph C. ^{[1
]}

Lanier, Lewis L. ^{[2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10021 USA

[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Div Rheumatol, Dept Med, San Francisco, CA 94143 USA

来源：

IMMUNOLOGICAL REVIEWS | 2013年 / 253卷

关键词：

natural killer; NK; microRNA; development; cytotoxicity; NATURAL-KILLER-CELLS; ADAPTIVE IMMUNE-RESPONSES; IFN-GAMMA PRODUCTION; T-CELLS; TUMOR-SUPPRESSOR; INNATE IMMUNITY; DISTINCT ROLES; NUCLEAR EXPORT; ALPHA-BETA; C-MYB;

D O I：

10.1111/imr.12045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The important role of microRNAs in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific microRNAs in regulating the development and function of natural killer (NK) cells. Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation.

引用

页码：40 / 52

页数：13

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