Approaches to microRNA discovery

被引：390

作者：

Berezikov, Eugene ^{[1
]}

Cuppen, Edwin ^{[1
]}

Plasterk, Ronald H. A. ^{[1
]}

机构：

[1] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

NATURE GENETICS | 2006年 / 38卷 / Suppl 6期

关键词：

D O I：

10.1038/ng1794

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several hundred genes encoding miRNAs have been experimentally identified in animals, and many more are predicted by computational methods. How can new miRNAs be discovered and distinguished from other types of small RNA? Here we summarize current methods for identifying and validating miRNAs and discuss criteria used to define an miRNA.

引用

页码：S2 / S7

页数：6

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